With hundreds of slots and plenty of table games to keep the crew busy, Mark Twain Casino in La Grange is a winning vacation spot in Northeast MO. Complete with a beautifully landscaped and spacious RV Park, it’s a favorite of locals and visitors alike. We are located alongside the Mississippi River a few miles north of Hannibal MO on Hwy. 61. No matter what you’re looking for, at Mark Twain, it’s an odds-on favorite you’re going to have a great time!